identifier	taxonID	type	CVterm	format	language	title	description	additionalInformationURL	UsageTerms	rights	Owner	contributor	creator	bibliographicCitation
038687915151FFC7FFC5FCE0FC006CEC.text	038687915151FFC7FFC5FCE0FC006CEC.taxon	http://purl.org/dc/dcmitype/Text	http://rs.tdwg.org/ontology/voc/SPMInfoItems#GeneralDescription	text/html	en	Trichocomaceae	<div><p>Family Trichocomaceae Aspergillus versicolor</p> <p>Nicotiana tabacum derived Fungus CPA-Type indole alkaloids Anti-TMV activities</p> <p>A B S T R A C T</p> <p>Indole alkaloids have attracted widespread attention of chemists and biologists. Therefore, the aim of this study is to screen more bioactivities indole alkaloids from the microorganisms. In this study, five undescribed CPA-type indole alkaloids, aspergillines F–J, and three known CPA-type indole alkaloids, aspergilline A, aspergilline C, and cyclopiamide E, were obtained from the Nicotiana tabacum - derived fungus Aspergillus versicolor. Notably, aspergillines F and G represent the first examples of indole alkaloids with a benzo[cd]indol-2(1 H)-one skeleton, and aspergilline J is also the firstly obtained indole alkaloids bearing a N -1-(2-(1 H -imidazole-5-yl)ethyl) moiety. Aspergillines F–J and cyclopiamide E were tested for their anti-TMV activities, and the results revealed that aspergillines G and J exhibited obvious anti-TMV activities with inhibition rates of 41.2 and 56.8% at the concentration of 20 μ M, respectively. These rates are high than that of positive control (with inhibition rate of 32.5%). In addition, the molecular docking studies for the isolated CPA-type indole alkaloids may also reveal that the benzo[cd]indol-2(1 H)-one substructure is the fundamental for anti-TMV activity and the oxygen-containing substituent groups at C-19 also increases the inhibitory activity. This study of structure-activity relationship is helpful to find new anti-TMV activity inhibitors.</p> </div>	https://treatment.plazi.org/id/038687915151FFC7FFC5FCE0FC006CEC	Public Domain	No known copyright restrictions apply. See Agosti, D., Egloff, W., 2009. Taxonomic information exchange and copyright: the Plazi approach. BMC Research Notes 2009, 2:53 for further explanation.		Plazi	Yang, Guang-Yu;Dai, Jia-Meng;Mi, Qi-Li;Li, Zhen-Jie;Li, Xue-Mei;Zhang, Jian-Duo;Wang, Jin;Li, Yin-Ke;Wang, Wei-Guang;Zhou, Min;Hu, Qiu-Fen	Yang, Guang-Yu, Dai, Jia-Meng, Mi, Qi-Li, Li, Zhen-Jie, Li, Xue-Mei, Zhang, Jian-Duo, Wang, Jin, Li, Yin-Ke, Wang, Wei-Guang, Zhou, Min, Hu, Qiu-Fen (2022): Cyclopiazonic acid type indole alkaloids from Nicotiana tabacum-derived fungus Aspergillus versicolor and their anti-tobacco mosaic virus activities. Phytochemistry (113137) 198: 1-7, DOI: 10.1016/j.phytochem.2022.113137, URL: http://dx.doi.org/10.1016/j.phytochem.2022.113137
